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Period. 6 – 12 April 2020
COVID-19 Timebomb in the Global South

Commentary: Action Imperatives for COVID-19 in Africa

Reflections by Dr. Andrew Nevin, Price Waterhouse Cooper Nigeria, 5 April 2020 The Dahdaleh Institute invited Dr. Andrew Nevin, a Partner and Chief Economist at PWC Nigeria, to offer his views on [... ]one minute.

Reflections by Dr. Andrew Nevin, Price Waterhouse Cooper Nigeria, 5 April 2020

The Dahdaleh Institute invited Dr. Andrew Nevin, a Partner and Chief Economist at PWC Nigeria, to offer his views on core structural imperatives in dealing with COVID-19 in Africa beyond healthcare responses. In the absence of a climate effect, Dr. Nevin warns African countries are headed for a humanitarian crisis in part due to weak healthcare systems, vulnerable populations, limited risk messaging, overcrowded housing and other difficulties with socially distancing. He anticipates the impacts in Africa could include:
  • Significant reduction in daily wages;
  • Breakdown of food supply chains;
  • Inability of the public sector to function virtually;
  • Strong private sector response in managing their businesses;
  • Confusion about who is in charge, and
  • Lack of information.
Based on these anticipated impacts, Dr. Nevin identified the following non-health system related priorities for African countries for COVID-19:
  1. Direct transfers to the bottom of the pyramid to replace purchasing power;
  2. Ensuring that food supply chains keep working;
  3. Getting organized private sector to support the public sector (e.g. national emergency committees as decision-making bodies with government and industry partners);
  4. Rapid and coordinated economic support and debt relief by international finance institutions; and
  5. Reflect on possible structural change (e.g. economic decentralization) following response
related to Africa

How poorer countries are scrambling to prevent a coronavirus disaster

Amy Maxmen, Nature News, 1 April 2020 https://www.nature.com/articles/d41586-020-00983-9 The threat of a COVID-19 explosion across developing countries continues to grow. While the first dozen cases in Africa were detected in March, the [... ]a minute and a bit.

Amy Maxmen, Nature News, 1 April 2020

https://www.nature.com/articles/d41586-020-00983-9 The threat of a COVID-19 explosion across developing countries continues to grow. While the first dozen cases in Africa were detected in March, the virus likely arrived weeks or months before. Despite the rising incidence of test positive cases, limited testing and contact tracing capacity, political leadership and resource mobilization from donor nations has been lacking, despite calls from the WHO and the UN Secretary General. Many countries face underfunded healthcare systems, unreliable stocks of essential medicines, precarious access to health facilities, and frequent power outages. The Ebola outbreaks also showed that when health systems are overwhelmed by one infectious disease, many often die from a lack of care for malaria, pneumonia and other preventable diseases, as well as care during pregnancy and childbirth. At the same time, case reports from the peak of the epidemic in Wuhan, China suggest that an estimated 2.6 ICU beds were required per 10,000 adults. Italy has less than half that capacity and is overwhelmed. Many low-income countries, including those in sub-Saharan Africa, have less than one ICU bed per million people. Given the lack of well-funded health systems, countries in Africa are focusing on mitigation strategies to prevent COVID-19 from spreading as soon as they confirm their first cases. This includes shutting down most activities with the threat of arrest, rolling out tests to detect genetic sequences from the virus and a willingness to deploy rapid, easy-to-use tests(even if they are not as accurate as PCR tests that require lab capacity), and sequencing the genome of SARS-Cov-2 sampled from Nigeria.
related to AfricaChina

Some say there is a trade-off: save lives or save jobs – this is a false dilemma

Some say there is a trade-off: save lives or save jobs – this is a false dilemma (Heads of the IMF & WHO, Telegraph, 3 April 2020) Commentary by the IMF Managing [... ]less than a minute.
Some say there is a trade-off: save lives or save jobs – this is a false dilemma (Heads of the IMF & WHO, Telegraph, 3 April 2020) Commentary by the IMF Managing Director and the WHO Director General about the false dichotomy of save lives or save livelihoods. The argue that getting the virus under control is a prerequisite to saving livelihoods. Their joint appeal to policymakers, particularly in low- and middle-income countries, is to recognize that "protecting public health and putting people back to work go hand-in-hand." In addition to the WHO, which is actively providing technical assistance to its Member States, at least 85 countries have requested emergency financing from the IMF. As financing reaches the countries in need, the authors furthermore extend a joint plea "to place health expenditures at the top of the priority list," including paying salaries to healthcare workers, supporting hospitals, establishing field clinics, investing in medical and protective equipment, as well as carrying out public awareness campaigns such as hand washing.”

Research: COVID-19 pandemic in west Africa

COVID-19 pandemic in west Africa (Martinez-Alvarez et al, Lancet Global Health, 1 April 2020). Whether warmer temperatures will slow the spread of the COVID-19 virus has been a point of much speculation. [... ]less than a minute.
COVID-19 pandemic in west Africa (Martinez-Alvarez et al, Lancet Global Health, 1 April 2020). Whether warmer temperatures will slow the spread of the COVID-19 virus has been a point of much speculation. This hypothesis has led some European countries to adopt initial policies that rely on decreased transmission rates during the summer months, and the belief that African countries will face smaller epidemics than their European counterparts. No strong evidence base exists for such claims, however. The authors argue that COVID-19 has likely arrived later in west Africa than in Europe, and plot and present data that shows a similar rapid rate of community transmission in West African countries to rates of community transmission in European countries, once a case of COVID-19 has been confirmed. Nine of the25 poorest countries are in the west African region and  have poorly resourced health systems, rendering them unable to quickly scale up an epidemic response. The authors furthermore argue that the impact of a similar COVID-19 epidemic as currently seen in Europe would be devastating in west Africa.
related to AfricaEurope

Research on Forecasting Peak Transmission and Health System Utilization

Short-term forecasts of COVID-19 deaths in multiple countries Imperial College London, 8 April 2020 https://sangeetabhatia03.github.io/covid19-short-term-forecasts/index.html This weekly report by Imperial College London presents forecasts of transmission and mortality estimates over the coming [... ]two minutes.

Short-term forecasts of COVID-19 deaths in multiple countries

Imperial College London, 8 April 2020 https://sangeetabhatia03.github.io/covid19-short-term-forecasts/index.html This weekly report by Imperial College London presents forecasts of transmission and mortality estimates over the coming week for 42 countries with active transmission, accounting for the impact of control measures. The caveat with these forecasts is that accuracy varies with the quality of surveillance and reporting, i.e. presenting likely underestimates for countries with poor reporting. That said, based on transmissibility estimates, the COVID-19 epidemic is expected to demonstrate:
  • Stabilizing patterns in 14 countries (including Italy, Iran, Iraq, South Korea);
  • Slow-growth transmission (1<Rt<2) in Spain and Netherlands; and
  • Rapidly growing transmission (Rt>2) across 26 countries (including Algeria, Brazil, Canada, China, Egypt, France, Germany, India, Japan, Peru, Turkey, U.K. and U.S.).
Based on central forecasting trends, reported deaths in the coming week are expected to be:
  • Relatively small (<100) and large (100-1000) in 29 countries;
  • Large (1,000-5,000) in 8 countries (including Algeria, Brazil, Germany, Iran, and Turkey); and
  • Very large (5,000+) in 5 countries (France, Italy, Spain, U.K. and U.S).

New COVID-19 forecasts for Europe: Italy & Spain have passed the peak of their epidemics; UK, early in its epidemic, faces a fast-mounting death toll

Institute for Health Metrics and Evaluation, 7 April 2020 http://www.healthdata.org/news-release/new-covid-19-forecasts-europe-italy-spain-have-passed-peak-their-epidemics-uk-early-its New COVID-19 forecast from IHME found that among European nations, the peak daily death rate from the pandemic will occur during the third week of April, with the pandemic spreading from Southern Europe. According to current trajectories, 151,680 COVID-19 deaths could occur during the “first wave” of the pandemic in Europe, while the U.S. is expected to face 81,766 deaths. Declines in deaths are now occurring in Italy and Spain as most regions in the two countries have passed their peaks in the number of deaths, while other nations are approaching their peaks and still others facing peak mortality later in April. The death toll in many countries is compounded by demand for hospital resources well in excess of what is available. Predicted peaks in daily COVID-19 deaths appear to be highly variable among EEA countries, likely reflecting the equally variable ways that the novel coronavirus initially spread and then continued to affect Europe.

Projecting hospital utilization during the COVID-19 outbreaks in the United States

Moghadas et al, National Academy of Sciences, 3 April 2020 https://www.pnas.org/content/117/16/9122

Findings

Without isolation and with R0 = 2.5, treatment of critically ill patients at the outbreak peak would require 3.8x more ICU beds than exist in the U.S. (or 2x if R0 = 2). With self-isolation by 20% of cases within 24 hours of symptom onset, the outbreak trajectory would delay and flatten, and the number of ICU beds needed at the peak would reduce by 48.4% (or 73.5% if R0 = 2).

Interpretation

Hand washing and self-isolation is shown to significantly contribute to reducing the rate of spread of COVID-19, and therefore reducing the number of ICU beds needed at any one time. This could facilitate emergency mobilization to expand mobilization of critical care capacity to handle the burgeoning outbreak.
related to ItalySpainCanadaSouth KoreaIndiaJapanGermanyUnited KingdomUnited StatesNetherlandsTurkeyIran

Research on Transmission Dynamics and Efficacy of Face Masks

High Contagiousness and Rapid Spread of Severe Acute Respiratory Syndrome Coronavirus 2 Sanche et al, Emerging Infectious Disease EARLY RELEASE, 7 April 2020 https://wwwnc.cdc.gov/eid/article/26/7/20-0282_article Findings Initial estimates of the early dynamics of [... ]less than two minutes.

High Contagiousness and Rapid Spread of Severe Acute Respiratory Syndrome Coronavirus 2

Sanche et al, Emerging Infectious Disease EARLY RELEASE, 7 April 2020 https://wwwnc.cdc.gov/eid/article/26/7/20-0282_article

Findings

Initial estimates of the early dynamics of the outbreak in Wuhan suggest a doubling time of 2.3–3.3 days, which is less than half the time of prior estimates (6-7 days). Assuming a serial interval of 6–9 days, the authors also calculate a median basic reproductive number (R0) of 5.7 (95% CI 3.8–8.9) in the early stages of the pandemic, which is more than double existing estimates for R0 (2.2-2.7). Based on modelling of high-resolution domestic travel and infection data, the paper also shows that active surveillance, contact tracing, quarantine, and early strong social distancing efforts can slow transmission.

Interpretation

Dynamics of transmission for COVID-19 is not uniform and can be significantly higher in the early stages than previously thought.

Facemasks and similar barriers to prevent respiratory illness such as COVID-19: A rapid systematic review

Brainard et al, 6 April 2020, NOT YET PEER REVIEWED https://www.medrxiv.org/content/10.1101/2020.04.01.20049528v1

Findings

Based on a review of 31 studies (including 12 RCTs), the authors conclude that wearing face masks can be slightly protective against primary infection from casual community contact, and modestly protective against household infections when both infected and uninfected members wear face masks. Randomized Control Trials often suffered from poor compliance and controls using face masks, resulting in under-estimation of the protective effect, while observational studies exaggerated their efficacy.

Interpretation

The authors conclude that while the evidence is insufficient to support widespread use of face masks as a protective measure against COVID-19, there is enough evidence to support their use for short periods, especially vulnerable individuals and in transient high-risk environments.

Respiratory virus shedding in exhaled breath and efficacy of face masks

Leung et al, Nature Medicine, 3 April 2020 https://www.nature.com/articles/s41591-020-0843-2

Findings

Surgical face masks have been shown to effectively block the spread of seasonal coronaviruses in respiratory droplets, suggesting that masks can prevent transmission of COVID-19, which has been detected in both ‘coarse’ droplets and finer ‘aerosol’ droplets emitted by volunteers not wearing masks. Larger ‘coarse’ particles are carried by sneezes and coughs, whereas exhaled breath can spread ‘aerosol’ droplets, which have a diameter of five micrometres or less. Masks reduced detection of viral RNA in both types of droplets.

Interpretation

Face masks could prevent transmission of the novel coronaviruses and influenza viruses from symptomatic individuals.

Research: Clinical Public Health and Diagnosis

Preliminary estimates of the prevalence of selected underlying health conditions among patients with COVID-19 — United States, February 12–March 28, 2020 US CDC, WMWR Early Release, 3 April 2020 https://www.cdc.gov/mmwr/volumes/69/wr/mm6913e2.htm?s_cid=mm6913e2_w Findings Of [... ]a minute and a bit.

Preliminary estimates of the prevalence of selected underlying health conditions among patients with COVID-19 — United States, February 12–March 28, 2020

US CDC, WMWR Early Release, 3 April 2020 https://www.cdc.gov/mmwr/volumes/69/wr/mm6913e2.htm?s_cid=mm6913e2_w

Findings

Of the 7,162 patients with reported data on underlying factors, 37.6% had at least one underlying condition or risk factor, including diabetes mellitus (11%), chronic lung disease (9%), cardiovascular disease (9%). Underlying conditions and risk factors were significantly higher among ICU admissions (78%), while at least one underlying condition was reported in 94% of patients that died.

Interpretation

Preliminary estimates suggest that underlying risk factors and co-morbidities can play a significant role, particularly among severe cases that require ICU admission. It remains unknown, however, whether severity or level of control of underlying health conditions affects the risk for severe disease with COVID-19.

Loss of smell and taste in combination with other symptoms is a strong predictor of COVID-19 infection

Menni et al, 7 April 2020, NOT YET PEER REVIEWED https://www.medrxiv.org/content/10.1101/2020.04.05.20048421v1

Findings

This paper in pre-press shows preliminary evidence that anosmia (loss of smell) and ageusia (loss of taste) may be early symptoms of COVID-19. The study suggests that loss of taste and smell is a strong predictor of having been infected by the COVID-19 virus. Also, the combination of symptoms that could be used to identify and isolate individuals includes anosmia, fever, persistent cough, diarrhoea, fatigue, abdominal pain and loss of appetite. This is particularly relevant to healthcare and other key workers in constant contact with the public who have not yet been tested for COVID-19.

Research: Diagnostic Testing and Treatment

WHO lists two COVID-19 tests for emergency use 7 April 2020 https://www.who.int/news-room/detail/07-04-2020-who-lists-two-covid-19-tests-for-emergency-use WHO listed the first two COVID-19 diagnostic tests under the Emergency Use Listing Procedure. The move should help increase access [... ]less than two minutes.

WHO lists two COVID-19 tests for emergency use

7 April 2020 https://www.who.int/news-room/detail/07-04-2020-who-lists-two-covid-19-tests-for-emergency-use WHO listed the first two COVID-19 diagnostic tests under the Emergency Use Listing Procedure. The move should help increase access to quality-assured, accurate tests that can now be supplied by the UN and other procurement agencies supporting the COVID-19 response. The two in vitro diagnostics include: (1) genesig Real-Time PCR Coronavirus (Primerdesign, U.K.), an open system suitable for laboratories with moderate sample testing capacity, and (2) cobas SARS-CoV-2 Qualitative assay (Roche, U.S.) is a closed system assay for larger laboratories using the cobas 6800/8800 Systems.

The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro

Caly et al, Antiviral Research, 3 April 2020 https://www.sciencedirect.com/science/article/pii/S0166354220302011?via%3Dihub

Findings

Ivermectin is a widely available and used treatment for parasite infections in humans and animals, and it has an established safety profile for human use. It is also FDA-approved and appears on the WHO Model List of Essential Medicines. A single treatment of Ivermectin resulted in a 5,000-fold reduction in the SARS-Cov-2 virus at 48h in cell culture.

Interpretation

Ivermectin shows the potential to inhibit the causative virus in vitro. Further studies are needed to evaluate whether ivermectin has human clinical impact in limiting the viral load, preventing severe disease progression, and limiting person-person transmission.

An overview of the rapid test situation for COVID-19 diagnosis in the EU/EEA

European Centers for Disease Control, 1 April 2020 https://www.ecdc.europa.eu/sites/default/files/documents/Overview-rapid-test-situation-for-COVID-19-diagnosis-EU-EEA.pdf Timely and accurate laboratory testing is an essential part of the management of COVID-19 to slow transmission, support decisions on infection control strategies, and detect asymptomatic cases that could spread the virus further. At present, clinical public health guidelines (including by the WHO) recommend COVID-19 diagnosis by molecular testing which detect the virus RNA. However, these tests require well-equipped laboratory facilities, skilled technicians and expensive reagents. Infrastructure limitations and supply shortages are currently limiting testing capacity below the growing demand for COVID- 19 diagnostics. This report surveys the range of rapid diagnostic tests that are currently available - including rapid antigen testing - in order to alleviate the pressure on laboratories and expand testing capacity to meet the most urgent medical and public health needs.

Situation Summary: Humanitarian Response Locations

The number of confirmed cases and reported deaths have consistently increased by 10-20% per day over the past week, surpassing 7,300 and 250, respectively, across 23 locations with humanitarian responses. This does [... ]a minute and a bit.
The number of confirmed cases and reported deaths have consistently increased by 10-20% per day over the past week, surpassing 7,300 and 250, respectively, across 23 locations with humanitarian responses. This does not include countries like Iran where UN humanitarian agencies do not operate, and where the number of reported cases is 71,686, including 4,474 COVID-related deaths. The COVID-19 Global Humanitarian Response Plan by OCHA will be implemented by UN agencies, with international NGOs and consortiums playing a direct role in the response, but remains about 20% funded as of 8 April. The FAO published a framework for Addressing the Impacts of COVID-19 in Food Crises, including an appeal for US$110 million to maintain the provision of critical assistance where there are already high levels of need. The WFP estimates that 100-120 million people across 80 countries will require urgent support and food supplies. The UN High Commissioner for Human Rights issued renewed guidance on protection of human rights, calling for urgent and coordinated action by countries to prevent “wider inequalities and extensive suffering.” This is in light of reports by the IOM of increased restrictions at points of entry, limiting mobility and delivery of essential goods. Humanitarian organizations, including the ICRC and MSF have urged countries to protect vulnerable populations, including IDPs and asylum seekers. The combination of economic and social stresses, along with restrictive control measures, have led to a dramatic increase in the numbers of women and girls facing domestic abuse, as the UN Secretary General called for urgent measures to address the “horrifying global surge in domestic violence.”

Global Snapshot

April 9 marks the 100th day since the WHO was notified of the first case of “pneumonia of unknown cause” in Wuhan, China. As of April 12 at 10am EST, the total [... ]less than two minutes.
April 9 marks the 100th day since the WHO was notified of the first case of "pneumonia of unknown cause" in Wuhan, China. As of April 12 at 10am EST, the total worldwide deaths from COVID-19 has surpassed 110,000, as confirmed cases approach 1.8 million. The actual number of dead and infected worldwide are believed to be much higher, but testing shortages, different counting practices and concealment by some governments limit detection and reporting. The U.S. is the current global epicentre with over 530,000 confirmed cases and over 20,000 deaths, while the five worst affected countries (U.S., Spain, Italy, Germany, France) account for over 60% of all cases and almost 80% of deaths globally. Community transmission is spreading, and the rapid increase of cases across low- and middle-income countries has become a critical global issue, as over 20 developing countries are reporting more than 1,000 cases. The number of African cases increased approximately by 40% over the past week, with all 55 countries reporting cases and 8 African countries seeing exponential rise. South Africa’s border controls and lockdown over the past two weeks have significantly reduced the number of new cases. The economic fallout from the global pandemic could push 500 million people into poverty (8% of global population), according to a UN University report. This would be the first time that poverty has increased globally in over thirty years. The World Bank and IMF have scaled up and accelerated efforts to provide emergency funding to countries, while the UN Office for the Coordination for Humanitarian Affairs (OCHA) issued a US$2 billion appeal for a Coordinated Global Humanitarian Response Plan, which as of April 8, is only 20% funded. As governments confront the dual challenge of containing the viral pandemic and economic crisis, public health experts warn countries that premature re-opening could lead to a second wave of outbreaks, echoed as well by modelling projections in a recent Lancet paper. Oxfam has urged world leaders to contribute to the $2.5 trillion economic rescue plan set out by the UN to “keep poor countries and poor communities afloat.” Mounting job losses and disruptions to global supply chains are also expected to result in chronic food shortages, as countries are urged to keep trade open and to protect farmers.
related to United StatesSouth AfricaSpainItalyFranceGermany

Situation Summary: Africa

With just 2% of the world’s commercial air traffic, the novel Coronavirus took time to gain a foothold in Africa, but all 55 countries are now reporting cases. As of this morning, [... ]less than two minutes.
With just 2% of the world's commercial air traffic, the novel Coronavirus took time to gain a foothold in Africa, but all 55 countries are now reporting cases. As of this morning, there are 13,771 confirmed cases (40% weekly increase) and over 750 deaths across the continent. The Director of the Africa CDC warned that COVID-19 represents an "existential threat for our continent," as more than 20 countries have now reported at least 100 cases and local transmission is expected to surge over the following week. South Africa surpassed 2,000 confirmed cases, but has been praised for its proactive response, including early and strong border control and testing measures. The rate of new daily reported cases drastically reduced from 42% two weeks ago to an estimated 4% after the government imposed strict lockdown and border control measures. With expected community transmission, the lockdown has been extended to the end of April, and the government is actively preparing local health systems and rolling out mass testing and screening campaigns with winter approaching. Northern Africa remains the most affected region, as three countries are approaching 2,000 cases, including Egypt(1,939), Algeria (1,825), and Morocco (1,617). The UN and regional authorities have expressed particular concern over sub-Saharan Africa, as limited diagnostic testing kits and public health surveillance capacity is likely masking and further exacerbating local outbreaks. The African Centre for Strategic Studies has warned that South Sudan, the Democratic Republic of Congo, Sudan and Nigeria are particularly vulnerable to the spread of COVID-19. Healthcare workers are also acutely at risk, with 267 confirmed cases. More than 10 countries have also suspended vaccination campaigns, including the DRC where 6,500 children have died of measles since an outbreak was first reported in October 2018. France is taking an active role in supporting South Africa’s leadership in establishing a comprehensive regional action plan to assist African countries cope with the coronavirus pandemic. The UN Economic Commission for Africa has endorsed France’s proposal to impose a moratorium on African debt, calling for IMF Special drawing Rights of up to US$500 billion. The UN and regional authorities have expressed particular concern over sub-Saharan Africa, as limited diagnostic testing kits and public health surveillance capacity is likely masking and further exacerbating local outbreaks. Based on a targeted survey of risk factors, the African Centre for Strategic Studies has warned that South Sudan, the Democratic Republic of Congo, Sudan and Nigeria are particularly vulnerable to the spread of COVID-19.
related to South AfricaEgyptAlgeriaMoroccoAfricaSudanNigeria

Situation Summary: Asia

Based on official reports, China appears to have contained local transmission, as it has ended the 11-week lockdown of Wuhan. Neighbouring countries remain on high alert, however, as experts warn of second waves [... ]just over two minutes.
Based on official reports, China appears to have contained local transmission, as it has ended the 11-week lockdown of Wuhan. Neighbouring countries remain on high alert, however, as experts warn of second waves of outbreaks. This may have occurred in Singaporewhere record high daily case reports were confirmed this week, prompting countrywide closure of non-essential business and schools. An outbreak in Tokyo also led to the biggest weekly increase in Japan, as the government declared a month-long State of Emergency in major urban cities. South Korea, meanwhile, has limited new case reports to under 50 over the past week after pre-emptively expanding control measures and contact-tracing. In Iran, the number of reported cases and deaths are approaching 72,000, including almost 4,500 confirmed deaths. The government has asked the international community for economic sanction relief and emergency loans from the IMF, which the U.S. has opposed despite significant international pressure to sideline geopolitical tensions as countries attempt to respond to the pandemic. A Coalition of Arab Countries finally announced a two-week ceasefire in Yemen, following warnings by the WHO and UN a pending 'explosion' of cases that could cascade across the region. The WFP is set to halve aid to parts of Yemen's Houthi-controlled areas, however, as some donor countries have stopped their funding over concerns that aid deliveries were being obstructed by Houthi forces. The WFP feeds more than 12 million Yemenis a month, 80% of whom are in areas controlled by Houthi forces. In Jordan, strict curfews and other control measures appear to be suppressing transmission, while many Middle Eastern countries have also been more proactive in testing, even compared to European counterparts. Conflict-affected countries, however, remain acutely at risk of outbreaks, including Iraq (1,279), Afghanistan (555), and Palestine (268) after case reports doubled last week. New daily cases increased by 20% in the past two days in India to over 8,500, although there are concerns that the true outbreak size may be significantly higher than reported, as may also be the case in Pakistan (5,170) and Bangladesh (621). The Indian government has extended the national lockdown until the end of April, although wide-spread food shortages and a mass exodus from major urban areas has raised concern about local transmission in rural parts of the country. Japan has declared a month-long State of Emergency in major urban cities, including Tokyo where an outbreak led to the biggest daily increase in cases. A new study has warned of a second wave in countries like Japan, which appear to resemble the situation in Italy two weeks ago. Cases are climbing elsewhere in Southeast Asia, with Singapore reporting its highest number of new confirmed cases yesterday, after countrywide closure of non-essential business and schools took effect. The daily newly confirmed case count in South Korea has dropped to 50 for a third consecutive day following expansion of contact-tracing criteria.

Situation Summary: Americas

At 533,470 confirmed cases, the U.S. has more cases than the next four highest reporting countries combined, while also being the first country to surpass 20,000 COVID-related deaths. New York City continues [... ]a minute and a half.
At 533,470 confirmed cases, the U.S. has more cases than the next four highest reporting countries combined, while also being the first country to surpass 20,000 COVID-related deaths. New York City continues to be the epicentre of the pandemic with almost 200,000 cases, surpassing any other country. Multiple states are reporting that African-Americans are accounting for 60-80% of confirmed cases (while only 14% of U.S. population), which is being attributed to embedded structural inequities. Confirmed cases and deaths in Canada continue to increase by about 10% a day, surpassing 23,300 and 653, respectively. Based on transmission projections, the government this week announced that control measures, including physical distancing will likely continue until at least June. Early in the week, the U.S. CDC and Public Health Agency of Canada followed the WHO's shift in messaging by recommending face coverings in public where other social distancing steps are hard to maintain. Governments are exploring mobile phone-based surveillance measures that could violate civil liberties, while soldiers are being readied to assist with implementation of public health containment measures. The WHO Regional Office, PAHO, launched a $95 million appeal to support Latin American and Caribbean countries with priority public health measures. In Venezuela, a humanitarian crisis is emerging as chronic food and medical shortages have been exacerbated, prompting UNOCHA to fly in 90 tonnes of COVID-19 relief supplies this week. Off the coast of Uruguay, almost 60% of passengers and crew on board an Australian cruise ship have tested positive for COVID-19. In Ecuador, there has been an alarming 30% increase in confirmed cases to surpass 7,2000, as Chile and Peru are also approaching 7,000 cases. There is uncertainty in Brazil about the extent of the outbreak, as confirmed cases are approaching 21,000, while one researcher warns of a "mountain of deaths" beyond the over 1,150 officially reported. The government has stopped publishing official number of suspected cases, while only 54,000 test kits were distributed for a population of 210 million, leading to a mining company having to import 500,000 diagnostic kits this week.

Situation Summary: Europe

At least 14 countries are reporting more than 10,000 cases, as nine report over 1,000 deaths. With less than 17% of all confirmed cases globally, Italyand Spain continue to account for more than 35% of [... ]one minute.
At least 14 countries are reporting more than 10,000 cases, as nine report over 1,000 deaths. With less than 17% of all confirmed cases globally, Italyand Spain continue to account for more than 35% of all reported deaths (19,468 and 16,972, respectively). There has been optimism over the past week, however, as both countries have been reporting reductions in daily new confirmed cases and deaths. France and Turkey continue to experience significant daily increases in confirmed cases and deaths, reported cases at 129,654 and 52,167, respectively. The U.K. is likewise expected to see a drop in new cases and hospitalization, despite a record in daily reported deaths. Prime Minister Boris Johnson was moved out of Intensive Care yesterday after three days, stating ‘I owe them my life’ referring to NHS staff. Russia has also been raising concerns, as the number of reported cases continue to surge 10-20% for a third consecutive day, doubled in just four days to over 15,000, prompting China to close its border. Many European countries are also reporting high CFR near or above 10%, including Italy, Spain, France, the U.K., Netherlands, Belgium, and Sweden. This has been partly attributed to selective testing strategies, as a paper this week in BMJ suggests early and widespread testing may be contributing to Germany's relatively low CFR (2%). The European CDC has recommended that countries scale up testing and surveillance systems to guide and monitor the escalation and de-escalation of mitigation strategies.

COVID-19 Situation Report 83

WHO COVID-19 Situation Report 83 (12 April 2020) [... ]a few seconds.
WHO COVID-19 Situation Report 83 (12 April 2020)